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KMID : 0370220110550020154
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Yakhak Hoeji
2011 Volume.55 No. 2 p.154 ~ p.159
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Structure Activity Relationship of Methylchroman-2-carboxylic Acid N-(Disubstituted)phenylamide Derivatives as Potential NF-xB Inhibitors
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Kwak Jae-Hwan
Kim Young-Soo
Jung Jae-Kyeong
Lee Hee-Soon
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Abstract
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During the search for a novel compound that can inhibit NF-xB activation, 6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide (KL-1156) was identified as a good inhibitor of NF-xB activation. In the present study, we describe the synthesis of methylchroman-2-carboxylic acid N-(disubstituted)phenylamide derivatives (1 and 2 serieses). In addition, their inhibitory effects of NF-xB are compared with activity of KL-1156 and SAR (structure activity relationship) are explored.
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KEYWORD
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NF-xB, KL-1156, methylchroman, SAR
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